Reduction in mechanical ventilation: Necessary but not sufficient to prevent bronchopulmonary dysplasia in extremely preterm infants?

Bronchopulmonary dysplasia (BPD) is a severe chronic respiratory disease that develops over the first months after birth in preterm infants.1 Since the first description of BPD by Northway et al2, clinicians, investigators, and families of preterm infants have devoted substantial resources and effort towards preventing this consequential disease. During the past three decades, more than 25,000 very preterm infants have been enrolled into over 60 randomized trials of ∼40 different therapies that targeted BPD prevention as a primary or secondary outcome.

source https://www.jpeds.com/article/S0022-3476(21)01275-0/fulltext?rss=yes