A proposed framework for the clinical management of neonatal “culture-negative” sepsis

Neonatal septicemia (sepsis) remains a major cause of worldwide morbidity and mortality among term and preterm infants. The term “sepsis” originates from the Greek meaning “to rot.” The modern term came into use in 1914 and meant a change in symptomatology caused by infection and identified by a set of subjective and objective factors.1 In the 21st century, the generally accepted criterion is organ dysfunction accompanying infection. The consensus definition for sepsis has continued to evolve but remains difficult to define, particularly in the neonatal intensive care unit (NICU).

source https://www.jpeds.com/article/S0022-3476(22)00006-3/fulltext?rss=yes