Prolonged co-trimoxazole prophylaxis has no impact on child growth in the first two years of life: findings from a randomized controlled trial in Botswana

We investigated the impact of prolonged co-trimoxazole prophylaxis on growth in 2,848 HIV-exposed uninfected children enrolled in the Mpepu study, a randomized, placebo-controlled trial in Botswana. No significant differences in mean weight-for-age, length-for-age, or weight-for-length z-scores between placebo and co-trimoxazole arms were observed overall through 18 months.

source https://www.jpeds.com/article/S0022-3476(22)00281-5/fulltext?rss=yes