Reply

Cochius–den Otter et al raise an important point about the results of our recent randomized trial, which found that addition of intravenous sildenafil did not reduce treatment failure in infants receiving inhaled nitric oxide (iNO) for persistent pulmonary hypertension of the newborn (1). As they note, the dosing regimen tested in our randomized, placebo-controlled trial (0.1 mg/kg over 30 minutes, followed by a maintenance infusion of 0.72 mg/kg/day) mg/kg/hour) was roughly half of the highest dosing cohort studied by Steinhorn et al in a nonrandomized, dose-escalation study (0.4 mg/kg over 3 hours, followed by a maintenance infusion of 1.6 mg/kg/day) (2).

source https://www.jpeds.com/article/S0022-3476(22)00334-1/fulltext?rss=yes