Grand Rounds Hyperbilirubinemia Following Phototherapy In Glucose-6-Phosphate Dehydrogenase Deficient Neonates: Not Out Of The Woods

G6PD deficiency is a common cause of hazardous neonatal hyperbilirubinemia (HB) leading to the potentially devastating sequel of Kernicterus Spectrum Disorder (KSD), both in the US and worldwide (1,2,3). G6PD deficient newborns may be discharged as healthy from birth hospitalization, but subsequently develop a sudden and exponential increase in serum bilirubin to neurotoxic concentrations. A trigger of hemolysis may sometimes, but not always, be identified. Some G6PD deficient newborns readmitted for HB had been treated with phototherapy during their birth hospitalization, their HB having apparently resolved prior to discharge.

source https://www.jpeds.com/article/S0022-3476(23)00300-1/fulltext?rss=yes