Medical Progress Caffeine for Apnea of Prematurity: Too Much or Too Little of a Good Thing

Caffeine has become one of the most prescribed drugs in neonatal medicine.1-3 The effects of this medication on mortality, neonatal morbidities, and child development have been rigorously studied in the Caffeine for Apnea of Prematurity (CAP) trial.4-7 The World Health Organization (WHO) has included caffeine citrate in its short core list of essential medicines for neonates.8 However, caffeine remains unavailable or unaffordable in many middle-and-low-income countries.9 At the same time, regional and national guidelines are promoting potentially unsafe therapeutic drift in some high-income countries.

source https://www.jpeds.com/article/S0022-3476(23)00336-0/fulltext?rss=yes

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