The influence of puberty on body mass index change and pediatric non-alcoholic liver disease

I congratulate Khurana et al. for their publication entitled “Clinically Meaningful BMI Change Impacts Pediatric NAFLD”, and also for the excellent outcomes shared in the paper which reflects a very successful pediatric NAFLD multidisciplinary program.1 This retrospective study describes a BMI-z-score reduction of above 0.25 to be associated with significant improvements in NAFLD through reductions in serum aminotransferase levels. Patients who were successful in achieving BMI-z-score of above 0.25 appeared to be significantly younger (mean age and standard deviation 11.7+/-3.5 years) than those who did not (13+/-2.9 years).

source https://www.jpeds.com/article/S0022-3476(23)00314-1/fulltext?rss=yes